Pii: S0165-4608(01)00456-3

نویسندگان

  • Palma Finelli
  • Nicola S. Fracchiolla
  • Daniela Giardino
  • Giulietta Gottardi
  • Daniela Lambertenghi Deliliers
  • Agostino Cortelezzi
  • Lidia Larizza
  • Giorgio Lambertenghi Deliliers
چکیده

We report a t(8;12)(q12; p13) as the sole cytogenetic anomaly in a patient with a myelodysplastic syndrome (MDS). By means of FISH, we mapped the genomic region involved in the breakpoint (bkp) on both chromosomes. The 12p13 bkp mapped between markers WI-664 and WI-9218, immediately distal to the breakpoint cluster region frequently involved in hematological neoplasms targeted by y964C10. The 8q12 bkp (not yet investigated by FISH) was characterized and found to occur between markers WI-3263 and D8S524 within the region recognized by y874E10. © 2001 Elsevier Science Inc. All rights reserved.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pii: S0165-4608(01)00455-1

Spectral precision distance microscopy was utilized to detect small but nonetheless consistently present conformational differences between the immunoglobulin heavy-chain gene clusters (IgH) that reside on the two chromosome 12 homologues in all diploid cells of the mouse. The euclidian distance (i.e., the mean arithmetic three-dimensional [3-D] distance) between the 5 most IgH gene, C , and th...

متن کامل

Pii: S0165-1765(01)00360-3

This paper introduces specification tests for conditional moment restrictions. The proposed tests are generalizations of the Kolmogorov–Smirnov and Cramer–von Mises tests and they are consistent against all ] Œ alternatives to the null hypothesis, powerful against 1 / n local alternatives and not dependent on any smoothing parameter. A nonparametric bootstrap procedure based on recentered crite...

متن کامل

Pii: S0165-4608(01)00470-8

Cytogenetic analysis is useful in the diagnosis and to assess prognosis of B-cell chronic lymphocytic leukemia (B-CLL). However, successful cytogenetics by standard techniques has been hindered by the low in vitro mitotic activity of the malignant B-cell population. Fluorescence in situ hybridization (FISH) has become a useful tool, but it does not provide an overall view of the aberrations. To...

متن کامل

Pii: S0165-4608(01)00505-2

Cytogenetic studies can be useful in the clinical management of patients with leukemia. They may also give a clue to leukemogenesis and/or pathogenesis. Numerous disease-specific chromosomal aberrations have been and continue to be identified. Translocation (1;19)(q21 q23;p13.3) involving the long arm of chromosome 1 and the short arm of chromosome 19 is usually associated with acute lymphoblas...

متن کامل

Pii: S0165-4608(00)00370-8

An unusual cytogenetic rearrangement, described as ins(22;9)(q11;q34q21), was detected in a 49year-old male patient diagnosed with chronic myeloid leukemia (CML). Reverse transcriptase polymerase chain reaction (RT-PCR) revealed a b3a2 fusion transcript. In order to confirm the cytogenetic findings and fully characterize the inverted insertion, we performed fluorescence in situ hybridization (F...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2001